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| Researcher:
Janan
Jayawickramarajah, Candace, Lawrence |
| The aim of this project is to
exploit
synthetic organic chemistry to prepare molecules that incorporate
hydrogen
bond driven base-pairing interactions, in order to assemble discrete,
well
defined architectures. Such assemblies are envisioned to be
useful
for many applications including the study of energy- and
electron-transfer
processes in non-covalently assembled systems and the synthesis of
novel-reversible
polymeric materials. As importantly, these systems may help us to
enhance
our understanding of fundamental processes in nature such as
replication
and transport: |
| For
a recent review on this subject, please see: Sessler,
Jonathan L.;
Jayawickramarajah, Janarthanan. Functionalized base-pairs:
versatile
scaffolds for self-assembly. Chemical
Communications (2005),
(15), 1939-1949. |
| A G-quartet without templating
metal
cation |
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| A Guanosine-Cytidine Dinucleoside that Self-Assembles into a Trimeric Supramolecule |
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| A
pyrrole-appended purine nucleoside that competes with guanosine
self-assembly
through a proposed three-point Hoogsteen interaction |
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| References: |
| Sessler, J. L.; Sathiosatham, M.; Doerr, K.; Lynch, V.; Abboud, K. A. Angew. Chem. Int. Ed. 2000, 39, No.7 |
| Sessler, J. L.; Jayawickramarajah, J.; Sherman
C.
L.; Brodbelt, J. S. Enhancing
Hoogsteen Interactions: A pyrrole-containing
Purine Nucleoside that Competes with Guanosine Self-Assembly. J. Am. Chem.
Soc. 2004, 126, 11460-11461. |
| Sessler, J. L.; Jayawickramarajah, J.;
Sathiosatham,
M. Energy-and
electron-transfer in supramolecular systems. In Encyclopedia
of Supramolecular Chemistry; Atwood, J., Steed, J., Eds. Marcel
Dekker: New
York, 2004, pp 535-545. |
| Sessler, J. L.; Jayawickramarajah, J.;
Sathiosatham,
M.; Sherman, C. L.; Brodbelt, J. S. Novel
guanosine-cytidine dinucleoside
that self-assembles into a trimeric supramolecule. Org. Lett. 2003, 5 (15),
2627- 2630. |
| Page
Updated 11/5/04 Send Comments to Patricia Melfi |