On the other hand, We also use more traditional methods ... like polyacrylamide gel electrophoresis. Catalytic activity of RNAs provides a very powerful experimental probe for formation of the native state, and this catalytic activity is conveniently and rapidly monitored by denaturing electrophoresis.
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With all
those gels, our phosphorimager (Molecular Dynamics
Storm 820) gets used extensively. To the right of
the phosphorimager is another heavily-used piece
of equipment, our UV/Vis spectrophotometer (Beckman
DU800).
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